Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>

Physiological objectives and you can pharmacology away from curcumin

Guide ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin is the big part of brand new red color out of turmeric, an Indian spice which is obtained from the brand new rhizome of tropical plant Curcuma longa, and that belongs to the Zingiberaceae family unit members. Within this section, we talk about the pharmacological affairs out of curcumin and you may discuss the newest molecular bases of these circumstances. I then comment the latest demonstrated and you can possible clinical uses out of curcumin. Curcumin is famous historically given that a healing representative, however, their procedure from action are outlined. The pharmacological effects of curcumin be seemingly caused by an excellent synergism away from companies out of poor biochemical connections with numerous physiological purpose in interconnected signaling routes. This type of purpose tend to be nutrients particularly cyclooxygenase, lipoxygenase and you will necessary protein kinases, and you can transcription products such NF-?B, STAT and Nrf2. Modulation of those particles affects downstream affectors which make the newest antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you may antimicrobial things regarding curcumin. Such outcomes was looked at from inside the clinical products of curcumin getting soreness and inflammatory diseases, cancer tumors, Alzheimer problem, cardiovascular disease, and you will diabetes. The newest products have used varying amounts from curcuminwith more frequencies and cycle, for the standard conclusion that large dosages regarding curcumin at the level of g have to receive therapeutic consequences. Read more

Curcumin: Synthesis, Emerging Role when you look at the Aches Administration and Wellness Effects

Guide Section Examples of plant-derived pharmaceuticals with end up being the interest out-of persisted and you may great lookup and you will innovation attract provides, thus far, come a bit scarce. Immediately following several latvian ladies search years, the past 20 years was indeed described as a 100-fold upsurge in exactly how many scientific content blogged a-year that are off value towards the use of curcumin within the biomedicine. Read more

Framework, synthesis and physical affairs regarding curcumin prodrugs

Guide ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin has many possible pharmacological consequences and may even enjoys therapeutic applications in lots of state claims, because the discussed in more detail in the previous section. But not, the potential clinical efficacy away from curcumin is limited of the its physicochemical qualities out-of worst drinking water solubility and you may instability, which lead to reduced bioavailability. Prodrugs away from curcumin offer a way to improve of one’s biopharmaceutical and you can pharmacokinetic services, and may also enable it to be exploitation of one’s pharmacological aftereffects of curcumin. Within this chapter, we first opinion the latest physicochemical and you will pharmacokinetics off curcumin. I following identify the design of curcumin prodrugs having improved liquid solubility and you may enhanced chemicals balances which might be translated returning to totally free curcumin up on bioactivation into the vivo. We focus on present success in this area, that have a focus on the build, synthesis and you can review off prodrugs according to promoieties in addition to amino acids, efas, nucleic acids, dicarboxylic acids, and you will polymeric product such as for example hyaluronic acidic and you may polyethylene glycol. That it chapter gets the basis for optimisation of one’s physicochemical and you can biopharmaceutical attributes in addition to biological situations off curcumin prodrugs, toward objective having fun with of those curcumin derivatives during the medical apps. Find out more